Altered neural signatures of interoception in multiple sclerosis. Salamone PC, Esteves S, Sinay VJ, García-Cordero I, Abrevaya S, Couto B, Adolfi F, Martorell M, Petroni A, Yoris A, Torquati K, Alifano F, Legaz A, Cassará F, Bruno D, Kemp AH, Herrera E, García A.M., Ibáñez A, Sedeño L. 2018

AUTORES Salamone PC, Esteves S, Sinay VJ, García-Cordero I, Abrevaya S, Couto B, Adolfi F, Martorell M, Petroni A, Yoris A, Torquati K, Alifano F, Legaz A, Cassará F, Bruno D, Kemp AH, Herrera E, García A.M., Ibáñez A, Sedeño L.
AÑO 2018
JOURNAL Human Brain Mapp
VOLUMEN August 4, 2018
ABSTRACT Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of autonomic bodily information-a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing-remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner-signal monitoring in the body symptomatology of MS.
RESUMEN Este estudio muestra, por primera vez, que la esclerosis múltiple implica alteraciones en el procesamiento interoceptivo –a saber, el monitoreo automático de la información corporal. Nuestros resultados, basados en registros electrofisiológícos y de resonancia magnética estructural y funcional, sugieren que tales alteraciones podrían constituir un marcador crítico de las disfunciones de procesamiento corporal que presentan los pacientes. Nuestra perspectiva multidimensional abre una nueva agenda en la investigación de esta enfermedad.

22/9 – 10ma Caminata Nacional por el #Alzheimer de #FundaciónINECO

Luego de nueve exitosas ediciones realizadas previamente, con la iniciativa de Fundación INECO y para conmemorar el Día Internacional del Alzheimer, este 2018 llevaremos a cabo la 10° CAMINATA NACIONAL POR EL ALZHEIMER. Esta tendrá lugar el sábado 22 de septiembre, de 10 a 13 hs., en Plaza Sicilia, CABA, ubicada entre Av. Sarmiento y Av. del Libertador.

El recorrido contará con paradas con puestos de información sobre la enfermedad que padecen 500 mil personas en Argentina, y consejos para reducir el riesgo de desarrollarla. Una vez concluida la caminata, el Dr. Facundo Manes conversará con los participantes sobre el impacto en la Salud Pública de la Enfermedad de Alzheimer. Además, vamos a realizar sorteos para todos los participantes, actividades para una mayor concientización y más sorpresas.

La caminata también se realizará en localidades de toda la Argentina, Perú y Chile. ¡Los esperamos! #TodosSomosParte

📆 Inscripciones: http://goo.gl/FxssbJ
Más info: goo.gl/porVS1

Increased moral condemnation of accidental harm in institutionalized adolescents. Baez, S., Herrera, E., García, A. M., Huepe, D., Santamaría-García, H., & Ibáñez, A. 2018

 

AUTORES Baez, S., Herrera, E., García, A. M., Huepe, D., Santamaría-García, H., & Ibáñez, A.
AÑO 2018
JOURNAL Scientific Reports
VOLUMEN August 2, 2018
ABSTRACT Social deprivation, as faced by children in institutional rearing, involves socio-cognitive deficits that may persist into adolescence. In particular, two relevant domains which prove sensitive to pre-adult neurodevelopment are theory of mind (ToM) and moral judgment (a complex skill which partially depend upon ToM). However, no study has assessed moral evaluation in adolescents with a history of institutional care, let alone its relationship with ToM skills. The present study aims to bridge this gap, focusing on moral evaluation of harmful actions in institutionalized adolescents (IAs). Relative to adolescents raised with their biological families, IAs exhibited less willingness to exculpate protagonists for accidental harms, suggesting an under-reliance on information about a person’s (innocent) intentions. Moreover, such abnormalities in IAs were associated with ToM impairments. Taken together, our findings extend previous findings of delayed ToM under social deprivation, further showing that the development of moral cognition is also vulnerable to the impact of institutionalization. These results could pave the way for novel research on the role of institutional rearing in ToM and moral development during adolescence.
RESUMEN La deprivación social en adolescentes institucionalizados (AI) podría impactar en el neurodesarrollo de la teoría de la mente (ToM) y el juicio moral. Mostramos en este estudio que los AI (en comparación con controles) presentaron un patrón de cognición moral atípica (incremento de condena moral a acciones no intencionales), asociado a alteraciones de ToM. Nuestro estudio demuestra que el desarrollo de la cognición moral es vulnerable al impacto de la institucionalización.