Gleichgerrcht E, Ibanez A, Roca M, Torralva T, Manes F.  Decision-making cognition in neurodegenerative diseases. Nature Reviews Neurology 2010

Decision-making cognition in neurodegenerative diseases.

Autores Gleichgerrcht E, Ibanez A, Roca M, Torralva T, Manes F. 
Año 2010
Journal  Gleichgerrcht E, Ibanez A, Roca M, Torralva T, Manes F. 
Volumen 6(11): 611-623
Abstract  A large proportion of human social neuroscience research has focused on the issue of decision-making. Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease. Thus, examining the qualitative differences in decision-making impairments associated with different neurodegenerative diseases could provide valuable information regarding the underlying neural basis of decision-making. Nevertheless, few comparative reports of decision-making across patient groups exist. In this Review, we examine the neuroanatomical substrates of decision-making in relation to the neuropathological changes that occur in Alzheimer disease, frontotemporal dementia, Parkinson disease and Huntington disease. We then examine the main findings from studies of decision-making in these neurodegenerative diseases. Finally, we suggest a number of recommendations that future studies could adopt to aid our understanding of decision-making cognition.
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