The Extended Fronto-Striatal Model of Obsessive Compulsive Disorder: Convergence from Event-Related Potentials, Neuropsychology and Neuroimaging.
|Autores||Melloni M, Urbistondo C, Sedeño L, Gelormini C, Kichic R, Ibanez A.|
|Journal||Melloni M, Urbistondo C, Sedeño L, Gelormini C, Kichic R, Ibanez A.|
|Abstract||In this work, we explored convergent evidence supporting the fronto-striatal model of obsessive-compulsive disorder (FSMOCD) and the contribution of event-related potential (ERP) studies to this model. First, we considered minor modifications to the FSMOCD model based on neuroimaging and neuropsychological data. We noted the brain areas most affected in this disorder -anterior cingulate cortex (ACC), basal ganglia (BG) and orbito-frontal cortex (OFC)- and their related cognitive functions, such as monitoring and inhibition. Then, we assessed the ERPs that are directly related to the FSMOCD, including the error-related negativity (ERN), N200 and P600. Several OCD studies present enhanced ERN and N2 responses during conflict tasks as well as an enhanced P600 during working memory tasks. Evidence from ERP studies (especially regarding ERN and N200 amplitude enhancement), neuroimaging and neuropsychological findings suggests abnormal activity in the OFC, ACC and BG in OCD patients. Moreover, additional findings from these analyses suggest dorsolateral prefrontal and parietal cortex involvement, which might be related to executive function deficits. Thus, these convergent results suggest the existence of a self-monitoring imbalance involving inhibitory deficits and executive dysfunctions. OCD patients present an impaired ability to monitor, control, and inhibit intrusive thoughts, urges, feelings and behaviors. In the current model, this imbalance is triggered by an excitatory role of the BG (associated with cognitive or motor actions without volitional control) and inhibitory activity of the OFC as well as excessive monitoring of the ACC to block excitatory impulses. This imbalance would interact with the reduced activation of the parietal-DLPC network, leading to executive dysfunction. ERP research may provide further insight regarding the temporal dynamics of action monitoring and executive functioning in OCD.|
|Otra información||En este trabajo del LPEN y la Clínica de Ansiedad, mostramos que las bases cerebrales del TOC implican una afectación de la red de auto-monitoreo e inhibición (áreas frontoestriadas) y otra red de funciones ejecutivas (áreas dorsolateral prefrontal y parietal). Dicho modelo integra adecuadamente la evidencia de la clínica del TOC con sus bases neuroanatómicos.|