Struder B, Manes F, Humphreys G, Robbins TW.  Risk-Sensitive Decision-Making in Patients with Posterior Parietal and Ventromedial Prefrontal Cortex Injury. Cerebral Cortex 2013 10.1007/s00429-013-0510-1

Risk-Sensitive Decision-Making in Patients with Posterior Parietal and Ventromedial Prefrontal Cortex Injury.

Autores Struder B, Manes F, Humphreys G, Robbins TW. 
Año 2013
Journal  Struder B, Manes F, Humphreys G, Robbins TW. 
Volumen 25:1-9
Abstract  Successful choice under risk requires the integration of information about outcome probabilities and values and implicates a brain network including the ventromedial prefrontal cortex (vmPFC) and posterior parietal cortex (pPAR). Damage to the vmPFC is linked to poor decision-making and increased risk-taking. Electrophysiological and neuroimaging data implicate the pPAR in the processing of reward probability during choice, but the causal contribution of this area has not been established. We compared patients with lesions to the pPAR (n = 13), vmPFC (n = 13), and healthy volunteers (n = 22) on the Roulette Betting Task, a measure of risk-sensitive decision-making. Both lesion groups were impaired in adjusting their bets to the probability of winning. This impairment was correlated with the extent of pPAR, but not vmPFC, damage. In addition, the vmPFC group chose higher bets than healthy controls overall, an effect that correlated with lesion volume in the medial orbitofrontal cortex. Both lesion groups earned fewer points than healthy controls. The groups did not differ on 2 tasks assessing probabilistic reasoning outside of a risk-reward context. Our results demonstrate the causal involvement of both the pPAR and vmPFC in risk-sensitive choice and indicate distinguishable roles of these areas in probability processing and risk appetite.
Otra información  La elección acertada bajo riesgo requiere la integración de la información acerca de las probabilidades de los resultados y valores e involucra una red cerebral que incluye la corteza prefrontal ventromedial (vmPFC) y la corteza parietal posterior (pPAR). El daño a la vmPFC está vinculada a la mala toma de decisiones y a una mayor toma de riesgos. Datos electrofisiológicos y de neuroimagen implican la pPAR en el procesamiento de la probabilidad de recompensa durante la eleccion, pero la contribución causal de esta área no ha sido establecida. Se compararon pacientes con lesiones en la pPAR, vmPFC y voluntarios sanos en el Roulette Betting Task, una medida de la toma de decisiones del riesgo. Nuestros resultados demuestran la implicación causal tanto de la pPAR y y de la vmPFC en “in risk-sensitive choice ” e indican los roles diferenciados de estas áreas en el procesamiento de la probabilidad y apetito de riesgo.