Dr. Manes obtained his medical degree from the School of Medicine at the University of Buenos Aires, Argentina and his Master in Science from the University of Cambridge, England. As a medical student, he received the “Neurociencias 1992” award, granted by the Argentine Medical Association for his research work entitled "The role of the corpus callosum in interhemispheric cerebral transfer". During his medical education, he was an anatomy instructor at the School of Medicine and the School of Pharmacy and Biochemistry at the University of Buenos Aires.
He completed his residency program in Neurology at the Raúl Carrea Institute for Neurological Research (FLENI) and trained in Functional Neuroimaging in the Department of Neuroradiology, Massachusetts General Hospital, Harvard Medical School (Boston, USA), also completing a fellowship in neuropsychiatry in the Department of Psychiatry, University of Iowa (Iowa City, USA), where he was also a neuroanatomy instructor.
He worked as a neurologist and clinical investigator in the Departments of Neurology and Psychiatry, University of Cambridge, and is currently a consultant in Neurology and Neuropsychology in the Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, England.
Once finishing his postgraduate study abroad in England and the United States, he returned to Argentina determined to develop local resources in order to raise clinical and research standards in cognitive neuroscience, cognitive neurology and neuropsychiatry. He was initially the head of the Cognitive Neurology, Neuropsychology and Neuropsychiatry Section at the Raul Carrea Institute for Neurological Research (FLENI). He then founded INECO (The Institute of Cognitive Neurology) and the Institute of Neurosciences at Favaloro University in Buenos Aires. These institutions are considered state-of-the-art leading institutions in the field of neurosciences throughout Latin America and have become internationally recognized clinical research centers.
Dr. Manes has published over 170 original scientific works in the most prestigious international journals of his
field, such as Brain, JAMA Neurology and Nature Neuroscience. Besides, he has contributed several chapters for international books on neurology and psychiatry including the Kaplan & Sadock's Comprehensive Textbook of Psychiatry (Williams & Wilkins), Behaviour and Mood Disorders in Focal Brain Lesions (Cambridge University Press) and Neuropsychology of Emotion (Oxford University Press), among others.
Dr Manes has written four books, namely “Convivir con personas con Alzheimer u otras Demencias” (Living with people with Alzheimer or other dementia); “Tratado de Neuropsicología” (Handbook of Neuropsychology); and “Social Neuroscience of Psychiatric Disorders”, “Usar el Cerebro. Conocer nuestra mente para vivir mejor”. (Use your brain. Understanding our mind for a better standard of life).
Dr Manes frequently gives lectures regarding cognitive disorders around the world in international scientific forums, such as the Royal Society of Medicine (London) and the New York Academy of Sciences, among others. He was a consultant for the Health and Education of the Dana Foundation in New York. Facundo Manes is a reviser for numerous international scientific journals, including Brain, Journal of Neurology Neurosurgery and Psychiatry, Journal of Neurology, Journal of Alzheimer's Disease, Neuropsychologia, Social Neuroscience, Neurology, Psychological Medicine, CNS Spectrums, JINS, CORTEX, American Journal of Psychiatry, Schizophrenia Research, Behavioural Neurology, Human Brain Mapping, Journal of Clinical and Experimental Neuropsychology, Brain Structure and Function, Behavioral Neurology, Journal of Nervous and Mental Disease, Neuropsychology, Cortex, Neurology, Frontiers Neuroscience, Frontiers in Aging Neuroscience, Frontiers in Dementia, Journal of Alzheimer’s Disease, and Neuroimage.
He is also a scientific reviser for universities, government organizations and research foundations. Dr Manes is a member of the editorial board of the Neuropsychological Rehabilitation journal, a member of the Editorial Board of Current Psychiatry Reports and an Associate Editor for Frontiers in Dementia, Frontiers in Aging Neuroscience, and Frontiers in Neuroscience for Young Minds (Nature Publishing Company)
He has been distinguished with leading national and international awards, including the Training High-Level
Human Resources, granted by the Argentine Ministry of Education, the "Arturo Jauretche 2014" award and the Young Investigator Award 1999, granted by the American Neuropsychiatric Association. Facundo Manes is member of several national and international scientific societies, including the World Federation of Neurology Research Group on Aphasia and Cognitive Disorders, and the Society for Social Neuroscience. He is a past advisory international board member of the ICD-11 Expert Working Group on the Classification of Neurocognitive Disorders of the World Health Organization. Dr Manes is an author for the new diagnostic criteria for the behavioral variant of frontotemporal dementia and for the new classification of primary progressive aphasia and its variants proposed by an international working group. He is currently the principal investigator or co-principal investigator on several trials evaluating potential new therapies in Alzheimer’s disease. He is also an International Advisory Committee Member of the Frontotemporal Dementia Association.
Among his contributions, Dr. Manes has identified the prefrontal areas related to the decision-making processes;
together with Dr. Calder, he described the neural basis of anger, and the role of the insula in emotional and cognitive processes. Furthermore, he described, for the first time, emotional processing in the minimally conscious state with Dr. Bekinschtein. He proposed, together with Dr Ibáñez, a theory of the neural substrates of the specific pattern of social cognition impairment seen in several neuropsychiatric disorders. He also developed the first cognitive rehabilitation unit in Latin America using a holistic approach. His focus in research focuses mainly on the neurobiology of mental processes, particularly the role of the prefrontal cortex in decision-making, social cognition and the cognitive reserve in patients in the vegetative state. He is currently supervising PhD students and postdoctoral students in different projects involving executive functions, decision making and social cognition in neuropsychiatry disorders. His team has also focused on the development of ecological and highly demanding executive tasks as well as screening tests for the early detection of neuropsychological impairment in different types of dementia.
Facundo Manes strongly believes in promoting science among society. He hosted “Los Enigmas del Cerebro” (Mysteries of the Brain), a TV show that aired on Argentina during 2011. He has also written a large amount of articles for the national press. He wrote a bestseller called “Usar el cerebro” (Use your brain), a book about the
brain accessible to the general public. Currently, he is president of Favaloro University of Buenos Aires Argentina and professor of Neurology, Behavioral Neurology and Cognitive Neuroscience at Favaloro University and Professor of Experimental Psychology at the University of South Carolina, USA. Facundo Manes has been recently appointed Visiting Professor at Macquarie University (Sydney, Australia). He is the chairman of the Latin American Division of the Society for Social Neuroscience and president of the World Federation of Neurology Research Group for Aphasia, Dementia and Cognitive Disorders. He is a member of the Center for Cognitive & Social neuroscience global network and Partner Investigator of the Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders. Facundo Manes is Director of the University Diego Portales-INECO Foundation Core on Neuroscience in Chile and principal investigator of the National Scientific and Technical Research Council (CONICET) in Argentina. He is the President of the INECO Foundation for research in Neuroscience. The INECO Foundation (FINECO) is a non-profit organization, the purpose of which is to support research programs for the prevention, diagnosis, and treatment of neurological and psychiatric disorders. FINECO also promotes the scientific training of health professionals and raises awareness in the community about issues relating to neurology and psychiatry. Dr. Manes is convinced that the wealth of a country is measured through the value of human capital, education, science, and technology; and that through said factors lies the basis of social development.
Martino D, Strejilevich S, Manes F. Neurocognitive functioning in early-onset and late-onset older patients with euthymic bipolar disorder. International Journal of Geriatric Psychiatry 2012 28(2): 142-148.[PubMed] view
Sposato L, Gleichgerrcht E, Manes F. Letter Regarding Article “Neurocognitive Improvement After Carotid Artery Stenting in Patients With Chronic Internal Carotid ArteryOcclusion and Cerebral Ischemia. Stroke 2011 43(1): 10-11.[PubMed] view
Gleichgerrcht E, Roca M, Manes F, Torralva T. Comparing the clinical usefulness of the Institute of Cognitive Neurology (INECO) Frontal Screening (IFS) and the Frontal Assessment Battery (FAB) in frontotemporal dementia. . Journal of Clinical and Experimental Neuropsychology 2011 33(9): 997-1004.[PubMed] view
Gleichgerrcht E, Roca M, Manes F, Torralva T. Comparing the clinical usefulness of the INECO Frontal Screening (IFS) and the Frontal Assessment Battery (FAB) in Frontotemporal Dementia. Journal of Clinical and Experimental Neuropsychology 2011 33(9): 997-1004.[PubMed] view
Gleichgerrcht E, Torralva T, Roca M, Manes F. Utility of an abbreviated version of the executive and social cognition battery in the detection of executive deficits in early behavioral variant frontotemporal dementia patients. Journal of the International Neuropsychological Society 2010 16(4): 687-694.[PubMed] view
Max JE, Manes F, Robertson BA, Mathews K, Lancaster J. Prefrontal and executive attention network lesions and the development of attention-deficit/hyperactivity symptomatology. Journal of the American Academy of Child and Adolescent Psychiatry 2005 44(5): 443-450.[PubMed] view