Regazzoni C, Zamora R, Petrucci E, PIsarevsky A, Ariel Saad, De Mollein D, Luna CM, Poderoso JJ. Hospital and 1-year outcomes of septic syndromes in older people: a cohort study. The journals of gerontology 2008

Hospital and 1-year outcomes of septic syndromes in older people: a cohort study.

Autores Regazzoni C, Zamora R, Petrucci E, PIsarevsky A, Ariel Saad, De Mollein D, Luna CM, Poderoso JJ.
Año 2008
Journal  Regazzoni C, Zamora R, Petrucci E, PIsarevsky A, Ariel Saad, De Mollein D, Luna CM, Poderoso JJ.
Volumen 63(2): 210-212
Abstract  PURPOSE: Our objective was to describe the relationship between sepsis syndrome mortality and cognitive and physical disability in elderly persons. METHODS: A 1-year consecutive cohort study in clinical beds of a university hospital was performed. Variables were severity of sepsis syndrome, organ failure, functional status, age, sex, and positive cultures. Outcomes were in-hospital and 1-year mortalities. RESULTS: The study included 137 patients (>70 years), both sexes. Data from 116 (84.5%) patients were obtainable at 1-year follow-up. Forty-eight (35%) patients presented with sepsis (11/137, 8%) or severe sepsis (37/137, 27%). In-hospital mortality was 15.3% (0% for sepsis and 21.8% if severe) and increased with organ failure (p <.0001). One-year mortality was 54.78% (63/116), mostly related to severe sepsis; predictors were severe organ failure (p <.0001), prior functional status (p =.0005), and Mini-Mental State Examination (p =.03). Prior functional status and organ failure were independent predictors. CONCLUSIONS: In-hospital and 1-year mortality increased with septic syndrome severity, prior functional status, and organ failure.
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