García AM, Bocanegra Y, Herrera E, Moreno L, Carmona J, Baena A, Lopera F, Pineda D, Melloni M, Legaz A, Muñoz E, Sedeño L, Baez S, Ibáñez A. Parkinson’s disease compromises the appraisal of action meanings evoked by naturalistic texts. 2017

AUTORES García AM, Bocanegra Y, Herrera E, Moreno L, Carmona J, Baena A, Lopera F, Pineda D, Melloni M, Legaz A, Muñoz E, Sedeño L, Baez S, Ibáñez A.
AÑO 2017
JOURNAL Science Direct
VOLUMEN July 17, 2017
ABSTRACT The linguistic profile of Parkinson’s disease (PD) is characterized by difficulties in processing units which denote bodily movements. However, the available evidence has low ecological validity, as it stems from atomistic tasks which are never encountered in real life. Here, we assessed whether such deficits also occur for meanings evoked by context-rich narratives, considering patients with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively) and matched controls for each group. Participants read two naturalistic stories (an action text and a neutral text) and responded to questions tapping the appraisal of verb-related and circumstantial information. In PD-MCI, impairments in the appraisal of action meanings emerged alongside difficulties in other categories, but they were unique in their independence from general cognitive dysfunction. However, in PD-nMCI, deficits were observed only for action meanings, irrespective of the patients’ domain-general skills (executive functions and general cognitive state). Also, using multiple group discriminant function analyses, we found that appraisal of action meanings was the only discourse-level variable that robustly contributed to classifying PD-MCI patients from controls (with an accuracy of 88% for all participants and for each sample separately). Moreover, this variable actually superseded a sensitive executive battery in discriminating between PD-nMCI and controls (with a combined accuracy of 83% for all participants, correctly classifying 79.2% of patients and 87.5% of controls). In sum, action appraisal deficits seem to constitute both a hallmark of naturalistic discourse processing in PD and a sensitive subject-level marker for patients with and without MCI. Such findings highlight the relevance of ecological measures of embodied cognitive functions in the assessment of this population.
RESUMEN En este estudio, basado en un nuevo protocolo de lectura de textos narrativos, evaluamos la aprehensión de acciones en la enfermedad de Parkinson, considerando pacientes con y sin deterioro cognitivo leve (EP-DCL y EP-nDCL). Los pacientes con EP-DCL presentaron déficits en distintas categorías textuales, pero sólo la aprehensión de acciones resultó independiente de sus habilidades cognitivas generales. Los pacientes EP-nDCL sólo manifestaron déficits en dicha categoría. Además, esta variable permitió clasificar a más del 80% de los pacientes, lo cual sugiere que el procesamiento de acciones en textos naturalistas podría constituir un marcador robusto de esta enfermedad.