Brain transcriptome sequencing of a natural model of Alzheimer’s disease.
|Altimiras F, Uszczynska-Ratajczak B, Camara F, Vlasova A, Palumbo E, Newhouse S, Deacon R, Farias L, Loyola D, Hurley M, Vásquez R, Dobson R, Guigó R, Cogram P.
|Frontiers in Aging Neuroscience
|Alzheimer’s disease (AD) is a devastating illness causing the most common form of dementia and for which no therapy is currently available. Over the past three decades drugs that show efficacy in animals models of AD have failed in large-scale clinical trials, which indicates a disparity between preclinical animal studies and the reality of human disease. Here we describe further characterization of a natural model of AD, the rodent Octodon degus. The present study reports the first brain transcriptome analysis in O.degus. Differentially expressed genes previously linked to AD were found by RNA – sequencing. The novel O. degus brain transcriptome data was compared with brain transcriptome data from AD patients and common differentially expressed genes were found. The present study contributes to the characterization of O. degus as natural model of AD, thereby demonstrating that it is a valuable tool for Alzheimer ́s research.
|El Octodon degus (O. degus) es un roedor hystricomorfo endémico de Chile que presentan naturalmente algunos rasgos distintivos de la enfermedad de Alzheimer´s (EA) como fibrilares TAU y depósitos β-amiloides. El presente trabajo es el primer transcriptoma de cerebro de O. degus de animales de tipo EA frente a animales controles.